Increase of self-mutilation behavior in forelimb deaf-ferented rats, following stimulation of the dorsal raphe nucleus

  • Souteyrand J
  • Sarkis D
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The role of dorsal raphe nucleus (DRN) was studied in rats which develop scratching or/and self-mutilation after deafferentation of brachial plexus. The extent of the lesions was measured in four groups of deafferented rats. Two control groups: implanted and not implanted, a group of animals in which DRN was stimulated, and a group in which it was electrolytically destroyed. We observed an increase of scratching and self-mutilation in the implanted group but overall in the stimulated group, and no change in the abnormal behavior was provoked by DRN lesion. © 1985, Elsevier Scientific Publishers Ireland Ltd.. All rights reserved.

Author-supplied keywords

  • abnormal behavior
  • brachial plexus deafferented rats
  • chronic pain
  • dorsal raphe nucleus
  • stimulation

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  • J. P. Souteyrand

  • D. Sarkis

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