Increased expression of mitochondrial respiratory enzymes in the brain of epilepsy-prone, naive EL mice

  • Nakagawa Y
  • Mishima T
  • Murashima Y
 et al. 
  • 3

    Readers

    Mendeley users who have this article in their library.
  • 5

    Citations

    Citations of this article.

Abstract

The present studies demonstrate that expression of both type 5 and type 6 subunits of NADH dehydrogenase and the type 1 subunit of cytochrome oxidase is enhanced significantly in the brains of naive, epilepsy-prone EL mice. In contrast, no apparent change in expression occurred with type 1 and type 2 subunits of NADH dehydrogenase. When expression of type 5 and 6 subunits of NADH dehydrogenase was determined at 24 h after a single series of vestibular stimulation, significant down-regulation was detected. The expression of subunit 2 of NADH dehydrogenase augmented gradually after vestibular stimulation. The increased expression of these mitochondrial respiratory enzymes may reflect enhanced demand for energy due to inherent, spontaneous neuronal hyperactivity in the brains of EL mice. © 2002 Elsevier Science B.V. All rights reserved.

Author-supplied keywords

  • Cytochrome c oxidaxe
  • EL mouse
  • Epilepsy
  • NADH dehydrogenase
  • Vestibular stimulation

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Yukinori Nakagawa

  • Takanori Mishima

  • Yoshiya L. Murashima

  • Kiwao Nakano

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free