Indium(I) bromide-promoted stereoselective preparation of (E)-α,β-unsaturated ketones via sequential intermolecular aldol-type coupling/elimination reactions of α,α-dichloroketones with aldehydes

  • Peppe C
  • das Chagas R
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Abstract

Indium(I) bromide promotes the reaction of α,α-dichloroketones with aldehydes to produce (E)-α,β-unsaturated ketones, exclusively. The transformation occurs via two sequential reactions, an aldol-type coupling between the two carbonylic reagents followed by an elimination process. © 2006 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Aldol-type coupling
  • Carbon-carbon bond formation
  • Elimination reaction
  • Indium
  • Organoindium
  • Sequential chemical reactions

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