Induction of HSP90α heat shock mRNA after transient global ischemia in gerbil hippocampus

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Abstract

Distribution of heat shock protein (HSP) 90α mRNA induction after 10 min of transient global ischemia was investigated in gerbil hippocampus by in situ hybridization. A small amount of HSP90α mRNA was normally present in hippocampal cells and the mRNA was further induced with a peak at 8 h after ischemia. In hippocampal CA1 cells that are vulnerable to ischemia, HSP90α mRNA was continuously induced by 1 day and finally diminished at 2 days. The temporal profile of HSP90α mRNA induction in hippocampal CA1 cells was similar to that of HSP70 mRNA reported previously, suggesting a cooperative role of HSP90α with other HSPs after ischemia. © 1993.

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Kawagoe, J. ichi, Abe, K., Aoki, M., & Kogure, K. (1993). Induction of HSP90α heat shock mRNA after transient global ischemia in gerbil hippocampus. Brain Research, 621(1), 121–125. https://doi.org/10.1016/0006-8993(93)90306-8

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