Induction of HSP90α heat shock mRNA after transient global ischemia in gerbil hippocampus

  • Kawagoe J
  • Abe K
  • Aoki M
 et al. 
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Abstract

Distribution of heat shock protein (HSP) 90α mRNA induction after 10 min of transient global ischemia was investigated in gerbil hippocampus by in situ hybridization. A small amount of HSP90α mRNA was normally present in hippocampal cells and the mRNA was further induced with a peak at 8 h after ischemia. In hippocampal CA1 cells that are vulnerable to ischemia, HSP90α mRNA was continuously induced by 1 day and finally diminished at 2 days. The temporal profile of HSP90α mRNA induction in hippocampal CA1 cells was similar to that of HSP70 mRNA reported previously, suggesting a cooperative role of HSP90α with other HSPs after ischemia. © 1993.

Author-supplied keywords

  • Cerebral ischemia
  • Gerbil
  • Heat shock protein 90
  • In situ hybridization

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