Induction of seizures by air blast in gerbils: stimulus duration/effect relationship

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Abstract

In air blast-induced seizures in gerbils, there is a relationship between the duration of the air blast and the incidence of 'major' convulsions. An ET50 of 9.6 sec was determined in untreated controls; pretreatment with anticonvulsant drugs shifted the stimulus/effect curve to the right. This 'stimulus summation' phenomenon makes a clearly defined challenge necessary when drug effects are to be evaluated. © 1987.

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Frey, H. H. (1987). Induction of seizures by air blast in gerbils: stimulus duration/effect relationship. Epilepsy Research, 1(4), 262–264. https://doi.org/10.1016/0920-1211(87)90035-0

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