Influence of loxapine on the sleep-wakefulness cycle of the rat

Citations of this article
Mendeley users who have this article in their library.
Get full text


The sleep-wakefulness cycle was studied in 18 Wistar albino rats under the influence of Loxapine, a neuroleptic derived from oxazepine succinate. One single dose of the drug (0.4-1.6 mg/kg) had a marked effect in depressing the paradoxical sleep (PS), maximal within 30 min and lasting about 24 hr. Frequency and mean duration of PS episodes were differentially affected. Synchronized sleep was only slightly affected by Loxapine whereas no significant changes of wakefulness amount were detected. Chronic administration of the drug induced similar changes which disappeared in about 5 days. © 1974.




Schmidek, W. R., Timo-Iaria, C., Schmidek, M., Krakowiak, M., Alves, M. R., & Delmutti, E. E. (1974). Influence of loxapine on the sleep-wakefulness cycle of the rat. Pharmacology, Biochemistry and Behavior, 2(6), 747–751.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free