Influence of loxapine on the sleep-wakefulness cycle of the rat

  • Schmidek W
  • Timo-Iaria C
  • Schmidek M
 et al. 
  • 2

    Readers

    Mendeley users who have this article in their library.
  • 2

    Citations

    Citations of this article.

Abstract

The sleep-wakefulness cycle was studied in 18 Wistar albino rats under the influence of Loxapine, a neuroleptic derived from oxazepine succinate. One single dose of the drug (0.4-1.6 mg/kg) had a marked effect in depressing the paradoxical sleep (PS), maximal within 30 min and lasting about 24 hr. Frequency and mean duration of PS episodes were differentially affected. Synchronized sleep was only slightly affected by Loxapine whereas no significant changes of wakefulness amount were detected. Chronic administration of the drug induced similar changes which disappeared in about 5 days. © 1974.

Author-supplied keywords

  • Drugs and sleep
  • Loxapine
  • Paradoxical sleep
  • Pharmacology of sleep

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • W. R. Schmidek

  • C. Timo-Iaria

  • M. Schmidek

  • M. Krakowiak

  • M. R. Alves

  • E. E. Delmutti

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free