Inhalation studies of Mt. St. Helens volcanic ash in animals. II. Lung function, biochemistry, and histology

  • Raub J
  • Hatch G
  • Mercer R
 et al. 
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Abstract

Rats were exposed by inhalation to 9.4 mg/m3size-fractionated volcanic ash for 5 days (2 hr/day) and examined for changes in pulmonary function and histology for periods of up to 1 year. Fine-mode volcanic ash, SO2, and a combination of ash and SO2produced no observable effects in normal rats and rats with elastase-induced emphysema. However, there was a mild irritant response to SO2which was not influenced by the volcanic ash. Rats injected intratracheally with fine-mode volcanic ash or saline showed no evidence of pulmonary alterations after 6 months. Those injected with coarse-mode volcanic ash showed minor pulmonary functional changes, histologically detectable alveolitis, and small increases in lung weight. In contrast, quartz-injected rats showed large alterations in pulmonary function, lung weight, hydroxyproline levels, and large areas of lung consolidation and fibrosis. © 1985.

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Authors

  • James A. Raub

  • Gary E. Hatch

  • Robert R. Mercer

  • Margaret Grady

  • Ping Chuan Hu

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