Inhibition of mating by naloxone or morphine in recently castrated, but not intact male rats

  • Lieblich I
  • Baum M
  • Diamond P
 et al. 
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Administration of naloxone (SC 5 mg/kg) significantly reduced ejaculation and mounting in male rats in the weeks following castration. A similar effect was obtained by injecting morphine (SC 1 or 5 mg/kg). In contrast, the same dosages of naloxone or morphine did not affect the sexual performance of gonadally intact males. Opioid peptides may contribute to the temporary persistence of sexual behavior in testosterone-deficient male mammals, in which incentive qualities of the female partner are an important determinant of sexual arousal. © 1985.

Author-supplied keywords

  • Endophins
  • Morphine
  • Naloxone
  • Rat sexual behavior

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  • I. Lieblich

  • M. J. Baum

  • P. Diamond

  • N. Goldblum

  • C. Iser

  • C. G. Pick

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