Inhibition of phosphatidylinositol phosphodiesterase activity in skeletal muscle by metal ions and drugs which block neuromuscular transmission

  • Shute J
  • Smith M
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Abstract

The calcium-dependent phosphatidylinositol phosphodiesterase activity of skeletal muscle cytosol was determined. The enzyme was inhibited by Zn2+, Cu2+and Pb2+ions but Mg2+and Mn2+were without effect. The antimalarial drugs chloroquine and quinine and the aminoglycoside antibiotics gentamicin and neomycin all of which, like Zn2+, have been shown to block neuromuscular transmission, also inhibited the enzyme. © 1985.

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Authors

  • Janis K. Shute

  • Margaret E. Smith

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