The calcium-dependent phosphatidylinositol phosphodiesterase activity of skeletal muscle cytosol was determined. The enzyme was inhibited by Zn2+, Cu2+ and Pb2+ ions but Mg2+ and Mn2+ were without effect. The antimalarial drugs chloroquine and quinine and the aminoglycoside antibiotics gentamicin and neomycin all of which, like Zn2+, have been shown to block neuromuscular transmission, also inhibited the enzyme. © 1985.
CITATION STYLE
Shute, J. K., & Smith, M. E. (1985). Inhibition of phosphatidylinositol phosphodiesterase activity in skeletal muscle by metal ions and drugs which block neuromuscular transmission. Biochemical Pharmacology, 34(14), 2471–2475. https://doi.org/10.1016/0006-2952(85)90528-3
Mendeley helps you to discover research relevant for your work.