Inhibition of satiety by a cholecystokinin antagonist is independent of gastric emptying

  • Collins S
  • Weingarten H
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Abstract

The ability of a cholecystokinin antagonist Proglumide to inhibit satiety induced by intraperitoneal injections of cholecystokinin octapeptide (CCK-OP) and bombesin was examined in rats equipped with chronic gastric cannulae. Both CCK-OP and bombesin significantly suppressed sham feeding. Proglumide administered alone did not alter sham feeding but it abolished the suppression of feeding induced by CCK-OP. In contrast. Proglumide did not inhibit the effect of a low dose of bombesin, but partially inhibited satiety induced by a high dose of bombesin, thus confirming our previous findings. These results indicate that the effect of Proglumide is independent of its recently described effects on gastric emptying in rat. © 1984.

Author-supplied keywords

  • Bombesin
  • Cholecystokinin
  • Gastric emptying
  • Proglumide
  • Satiety
  • Sham feeding

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Authors

  • Stephen M. Collins

  • Harvey P. Weingarten

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