Inhibition of satiety by a cholecystokinin antagonist is independent of gastric emptying

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Abstract

The ability of a cholecystokinin antagonist Proglumide to inhibit satiety induced by intraperitoneal injections of cholecystokinin octapeptide (CCK-OP) and bombesin was examined in rats equipped with chronic gastric cannulae. Both CCK-OP and bombesin significantly suppressed sham feeding. Proglumide administered alone did not alter sham feeding but it abolished the suppression of feeding induced by CCK-OP. In contrast. Proglumide did not inhibit the effect of a low dose of bombesin, but partially inhibited satiety induced by a high dose of bombesin, thus confirming our previous findings. These results indicate that the effect of Proglumide is independent of its recently described effects on gastric emptying in rat. © 1984.

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Collins, S. M., & Weingarten, H. P. (1984). Inhibition of satiety by a cholecystokinin antagonist is independent of gastric emptying. Peptides, 5(3), 481–484. https://doi.org/10.1016/0196-9781(84)90073-1

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