Inhibitory effect of a mixture of herbal drugs (TJ-960, SK) on pentylenetetrazol-induced convulsions in El mice

  • Sugaya E
  • Ishige A
  • Sekiguchi K
 et al. 
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Abstract

TJ-960 is a spray-dried mixture of 9 herbal drugs. The convulsions of El mice induced by pentylenetetrazol (18 mg/kg) were completely inhibited by p.o. administration of TJ-960 at a daily dose of 1.0 g/kg both in 8-week-old and 4-week-old El mice. These findings suggest that TJ-960 has an inhibitory effect on the convulsions of this hereditary animal model of epilepsy. © 1988.

Author-supplied keywords

  • Anticonvulsant
  • Epilepsy animal model
  • Herbal medicine
  • Pentylenetetrazol
  • SK
  • TJ-960

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Authors

  • Eiichi Sugaya

  • Atsushi Ishige

  • Kyoji Sekiguchi

  • Susumu Iizuka

  • Akira Sugimoto

  • Mitsutoshi Yuzurihara

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