Interaction of ofloxacin-Al(III) pH dependent complexes with the water|1,2-dichloroethane interface

Abstract

The transfer of Al(III)-ofloxacin (OFX) complexes across the water|1,2-dichloroethane interface was investigated using cyclic voltammetry and potential steps followed by a negative scan. The electrochemical response was determined by the pH of the solutions analyzed. At pH < 3 the main species in solution is HOFX+ whose diffusion controlled transfer is observed. At pH≫pKa2 highly hydroxylated species of Al(III) become important, inhibiting the complex formation and, as a result, a profile similar to that of the base solutions is obtained. In the range 3