Interference of chemicals with glycogen metabolism in isolated hepatocytes

Citations of this article
Mendeley users who have this article in their library.
Get full text


Freshly isolated hepatocytes in suspension were used to evaluate the possible effects of certain chemicals. Conditions including the choice of the incubation medium have been defined for maintaining the cells competent for a sufficient length of time. Using paracetamol alone or in combination with diethylmaleate, we have been able to show that these chemicals markedly alter the metabolic state of the cells, as indicated by an inhibition of glycogen synthesis and even by an enhancement of glycogen degradation, without modifying membrane integrity. These effects are dose-dependent and probably mediated through modification of glycogen phosphorylase activity. © 1980.




Krack, G., Goethals, F., Deboyser, D., & Roberfroid, M. (1980). Interference of chemicals with glycogen metabolism in isolated hepatocytes. Toxicology, 18(3), 213–223.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free