Transneuronal interference in microelectrophoretic studies has been investigated in the motor cortex of unanaesthetized cats. A special electrode assembly was used, which consisted of a combination of one single and a five-barrel micropipette attached in parallel, with various intertip distances. Simultaneous recordings from both electrodes were obtained. Electrode position was verified histologically at the end of each successful experiment. Our results show that transneuronal effects contribute to the results obtained from iontophoretic studies and that these effects may occassionally predominate, if favoured by conditions of substance application. These findings are discussed in relation to the significance they might have in interpreting results from iontophoretic studies and to their bearing on motor cortical physiology. © 1974.
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