This chapter focuses on intracellular membrane traffic. It discusses the carriers used and the sites and mechanisms for sorting and directing such traffic. A well-studied route of membrane traffic is the exocytosis pathway, which is known to be the general mode for release of secretory products from exocrinc, endocrine, and immunoglobulin-secreting cells. In the case of the basolateral plasmalemmal domain beyond the occluding junctions, which in polarized cells has a different composition than the apical domain, there is a separate pathway for delivery of membrane constituents. Pathway from the plasmalemma to the Golgi complex is also discussed. This is a major pathway in secretory cells producing proteins for export, and indirect evidence suggests that a large fraction of this traffic is connected with the retrieval and recycling of secretory granule membranes. The question remains whether the route taken by recovered membrane to reach the Golgi complex in secretory cells is direct or indirect, involving a stopover in lysosomes, or in some intermediate compartment. © 1983, Elsevier Inc. All rights reserved.
Mendeley saves you time finding and organizing research
Choose a citation style from the tabs below