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Skin biopsies were obtained before and after PUVA therapy from five psoriatic patients and epidermal melanocytes surveyed for the presence of intranuclear melanosome-like bodies and nuclear bodies. Intranuclear melanosome-like bodies were observed after PUVA therapy whereas none were found before therapy. Nuclear bodies were found to increase in frequency after PUVA therapy. Remnants of a nuclear envelope membrane were not found around the intranuclear melanosome-like bodies. Nor were remnants of a nuclear envelope membrane found in or around the nuclear bodies. The results are discussed in view of the possible sites of origin of intranuclear melanosome-like bodies and nuclear bodies. © 1983 Academic Press, Inc.




Ree, K. (1983). Intranuclear inclusions containing melanosomes observed after PUVA therapy: A study of five psoriatic patients. Journal of Ultrasructure Research, 83(1), 10–20. https://doi.org/10.1016/S0022-5320(83)90060-6

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