Isolation and characterization of variant IGF-1 as well as IGF-2 from adult human brain

  • Carlsson-Skwirut C
  • Jörnvall H
  • Holmgren A
 et al. 
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Abstract

The forms of somatomedin present in the adult human brain have been characterized in this study. Two peptides were purified by acidification, size exclusion chromatography, affinity chromatography, FPLC and HPLC. structural analysis identified these peptides as the variant form of IGF-1 with a truncated N-terminal region earlier isolated from human fetal brain and IGF-2. The presence of the truncated IGF-1 variant and IGF-2 in the human CNS suggests their role as neuropeptides. © 1986.

Author-supplied keywords

  • Amino acid sequence
  • Central nervous system
  • Insulin-like growth factor 1
  • Insulin-like growth factor 2
  • Neuropeptide
  • Somatomedin

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Authors

  • Christine Carlsson-Skwirut

  • Hans Jörnvall

  • Charlotte Andersson

  • Tomas Bergman

  • Gunilla Lundquist

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