K252a is a potent and selective inhibitor of phosphorylase kinase

  • Elliott L
  • Wilkinson S
  • Sedgwick A
 et al. 
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Abstract

The inhibition of phosphorylase kinase by a number of protein kinase inhibitors was examined. Both K252a and staurosporine are potent inhibitors of phosphorylase kinase with IC50values of 1.7 nM and 0.5 nM respectively. K252a shows a 300-fold selectivity for this enzyme over protein kinase C whereas staurosporine shows only a 20-fold selectivity for phosphorylase kinase. In contrast, the Roche bis-indolyl maleimides inhibit phosphorylase kinase with IC50values of approximately 1 μM and are highly selective for protein kinase C. © 1990.

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Authors

  • Lucy H. Elliott

  • Sandra E. Wilkinson

  • Anthony D. Sedgwick

  • Christopher H. Hill

  • Geoffrey Lawton

  • Peter D. Davis

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