Kinetics of gossypol inhibition of bovine lactate dehydrogenase X

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Abstract

Gossypol, a polyphenolic binaphthalene dialdehyde isolated from cotton meal is a potent inhibitor of lactate dehydrogenase-X purified from bovine testis. For the conversion of pyruvate to lactate the IC50for gossypol is 200 μM for the reverse reaction the IC50is 12 μM. Gossypol is a competitive inhibitor of NADH, Ki = 30 μM (Km = 17 μM), and NAD+, Ki = 6 μM (Km = 130 μM), and noncompetitive for pyruvate, Ki = 220 μM (Km = 224 μM), and lactate, Ki = 52 μM (Km = 5.6 mM). © 1983.

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Olgiati, K. L., & Toscano, W. A. (1983). Kinetics of gossypol inhibition of bovine lactate dehydrogenase X. Biochemical and Biophysical Research Communications, 115(1), 180–185. https://doi.org/10.1016/0006-291X(83)90986-5

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