Does the lactose carrier of Escherichia coli function as a monomer?

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Abstract

The purified lactose carrier of Escherichia coli (product of the lacY gene) is shown to be a monomer in detergent micelles of dodecyl-O-β-D-maltoside. The negative-dominant phenotype of mutant carriers (lacY-d mutants) could not be verified by measurements of the rate of galactoside transport in lacY+/Y-d diploid strains. It is proposed that the membrane-embedded carrier functions as a monomer in galactoside-H+ symport. © 1983.

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Keith Wright, J., Weigel, U., Lustig, A., Bocklage, H., Mieschendahl, M., Müller-Hill, B., & Overath, P. (1983). Does the lactose carrier of Escherichia coli function as a monomer? FEBS Letters, 162(1), 11–15. https://doi.org/10.1016/0014-5793(83)81039-4

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