Langerhans cell histiocytosis, a new clinical phenotype of x-linked lymphoproliferative disease?

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Abstract

Langerhans' cell histiocytosis (LCH) is a rare disease of unkown cause and is characterized by clonal proliferation of Langerhans cells. Here, we describe the case of a 22-month-old boy with LCH associated with X-linked lymphoproliferative disease (XLP). Sequence analysis of SH2D1A for mutations that cause T-cell dysfunction revealed a CT substitution at nucleotide 462. This is the first case that hints at an association between XLP and LCH. © 2010 Elsevier Masson SAS.

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Zhang, X., Zhu, D., Lan, H., Yu, L., Peng, W., Mei, Y., & Feng, Z. (2011). Langerhans cell histiocytosis, a new clinical phenotype of x-linked lymphoproliferative disease? European Journal of Medical Genetics, 54(2), 165–168. https://doi.org/10.1016/j.ejmg.2010.11.006

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