Lanthionine, a protein cross-link in cataractous human lenses

  • Bessems G
  • Rennen H
  • Hoenders H
  • 3


    Mendeley users who have this article in their library.
  • 20


    Citations of this article.


Oxidative processes are suggested to be a main cause of the covalent cross-linking of lenticular proteins. For a major part these cross-links are disulfides (cystine). With progression of nuclear cataract, cystine may be oxidized further to cysteic acid. Another oxidative degradation product of cystine is the symmetric thioether lanthionine. In this study, we clearly demonstrate that lanthionine is a protein cross-link of cataractous human lenses. Possible mechanisms of its formation are discussed. © 1987 Academic Press Inc. (London) Limited.

Author-supplied keywords

  • cataract
  • cross-link
  • cystine
  • free radicals
  • insoluble lens protein
  • lanthionine

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • George J H Bessems

  • Huub J J M Rennen

  • Herman J. Hoenders

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free