An X-ray detector system for macromolecular crystallography based on a large area charge-coupled device (CCD) sensor has been developed as part of a large research and development programme for advanced X-ray sensor technology, funded by industry and the Particle Physics and Astronomy Research Council (PPARC) in the UK. The prototype detector consists of two large area three-sides buttable charge-coupled devices (CCD 46-62 EEV), where the single CCD area is 55.3 mm×41.5 mm. Overall detector imaging area is easily extendable to 85 mm×110 mm. The detector consists of an optically coupled X-ray sensitive phosphor, skewed fibre-optic studs and CCDs. The crystallographic measurement requirements at synchrotron sources are met through a high spatial resolution (2048×1536 pixel array), high dynamic range (∼105), a fast readout (∼1 s), low noise (<10 e-1) and much reduced parallax error. Additionally, the prototype detector system has been optimised by increasing its efficiency at low X-ray energies for use at conventional lab sources. The system design of the prototype detector is discussed and the proposed method for crystallographic data processing is briefly outlined. © 2002 Elsevier Science B.V. All rights reserved.
Pokri, M., Allinson, N. M., Jorden, A. R., Cox, M. P., Marshall, A., Long, P. G., … Helliwell, J. R. (2002). Large area high-resolution CCD-based X-ray detector for macromolecular crystallography. In Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment (Vol. 477, pp. 166–171). https://doi.org/10.1016/S0168-9002(01)01881-2