Leccinine A (1) along with a known compound (2), were isolated from the edible mushroom Leccinum extremiorientale. The structure of 1 was determined by the interpretation of spectral data. Leccinine A showed protective activity against endoplasmic reticulum stress-dependent cell death. Seven analogues (3-9) of 1 were synthesized in order to evaluate the structure-activity relationship, and the result indicated that the formamide group of 1 was indispensable for the activity. © 2011 Elsevier Ltd. All rights reserved.
Choi, J. H., Ozawa, N., Yamakawa, Y., Nagai, K., Hirai, H., & Kawagishi, H. (2011). Leccinine A, an endoplasmic reticulum stress-suppressive compound from the edible mushroom Leccinum extremiorientale. Tetrahedron, 67(35), 6649–6653. https://doi.org/10.1016/j.tet.2011.05.052