Leccinine A, an endoplasmic reticulum stress-suppressive compound from the edible mushroom Leccinum extremiorientale

  • Choi J
  • Ozawa N
  • Yamakawa Y
 et al. 
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Abstract

Leccinine A (1) along with a known compound (2), were isolated from the edible mushroom Leccinum extremiorientale. The structure of 1 was determined by the interpretation of spectral data. Leccinine A showed protective activity against endoplasmic reticulum stress-dependent cell death. Seven analogues (3-9) of 1 were synthesized in order to evaluate the structure-activity relationship, and the result indicated that the formamide group of 1 was indispensable for the activity. © 2011 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Endoplasmic reticulum stress suppression
  • Leccinum extremiorientale
  • Mushroom
  • Structural determination

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Authors

  • Jae Hoon Choi

  • Nobuhiko Ozawa

  • Yasuhiro Yamakawa

  • Kaoru Nagai

  • Hirofumi Hirai

  • Hirokazu Kawagishi

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