Long-lasting effects of chronic μ-opioid intake on the signal transmission via dopamine D1receptors in the limbic forebrain of drug deprived rats

  • May T
  • Juilfs F
  • Wolffgramm J
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Abstract

Rats orally self-administered the potent and selective μ-opioid receptor agonist etonitazene for 8 weeks (free choice between three opioid solutions and water resulting in low drug intake, or forced intake of a single drug solution resulting in high opioid consumption). The signal transmission in membranes of the limbic forebrain (nucleus accumbens and olfactory tubercle) was studied during acute withdrawal (2 days of abstinence) and after 6 weeks of drug deprivation. Binding experiments with the dopamine (DA) D1receptor antagonist [3H]SCH23390 revealed in the high consuming rats an increased binding density (B(max)) by 19% during withdrawal and a decreased B(max) by 17% after long-term abstinence compared with drug-naive controls (each P

Author-supplied keywords

  • Abstinence
  • Adenylyl cyclase
  • Dopamine D1receptor
  • Opioid
  • Oral self-administration
  • Withdrawal

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Authors

  • Torsten May

  • Folkert Juilfs

  • Jochen Wolffgramm

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