L'ostéomalacie oncogène: Rôle des phosphatonines. Intérêt du dosage du fibroblast growth factor 23 démontré chez un malade

  • Dupond J
  • Magy N
  • Mahammedi M
 et al. 
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Abstract

Introduction. - Oncogenic osteomalacia (OO) is a rare paraneoplastic syndrome characterized by severe hypophosphatemia induced by phosphaturic factors which are secreted by some tumors of mesenchymal origin. Fibroblast Growth Factor 23 (FGF-23) belongs to this family. Measurement of FGF-23 might improve the diagnosis of OO. Exegesis. - We report the case of 71-year-old Caucasian man who had a history of severe osteomalacia with multiples fractures and extreme hypophosphatemia with hyperphosphaturia and normal serum calcium level. Serum FGF-23 was 199 RU/ml (N

Author-supplied keywords

  • FGF-23
  • Hypophophatemia
  • Oncogenic osteomalacia
  • Paraneoplastic syndrome
  • Phosphatonins
  • Phosphaturic mesenchymal tumors

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Authors

  • J. L. Dupond

  • N. Magy

  • M. Mahammedi

  • D. Prie

  • H. Gil

  • N. Meaux-Ruault

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