Lymphocytes T régulateurs et maladies auto-immunes systémiques: Lupus érythémateux systémique, polyarthrite rhumatoïde et syndrome de Gougerot-Sjögren primaire

12Citations
Citations of this article
4Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Regulatory/suppressor T cells (Tregs) maintain immunologic homeostasis and prevent autoimmunity. They are the guardians of dominant tolerance. Recent research reveals quantitative and/or functional defect of Tregs in systemic autoimmune diseases. In this article, past and recent studies of Tregs in human systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and primary Sjögren's syndrome (pGSS) are reviewed. Most studies report that Tregs are decreased in peripheral blood of subjects with active SLE. A population of CD4+CD25-Foxp3+ is specifically described in SLE. Tregs functions are still discussed. Tregs counts in peripheral blood of RA patients vary across studies. Enrichment of synovial fluid in Tregs contrasts with inflammation. Tregs suppressive effects are altered in vivo in RA secondary to proinflammatory cytokines environment and resistance of effector T cells to Tregs. In pGSS, the conflicting place of Tregs in the balance prevention of autoimmunity/antitumor immunity is unspecified. Immunosuppressive treatments, like corticosteroids and anti-TNF, modulate Tregs cells population. There is increasing interest in the use of Tregs as a biological therapy to preserve and restore tolerance to self-antigen. However, difficulties to characterize these lymphocytes and controversies in the results of studies refrain their use in current clinical practice. © 2009 Société nationale française de médecine interne (SNFMI).

Cite

CITATION STYLE

APA

Bernard, F., Romano, A., & Granel, B. (2010, February). Lymphocytes T régulateurs et maladies auto-immunes systémiques: Lupus érythémateux systémique, polyarthrite rhumatoïde et syndrome de Gougerot-Sjögren primaire. Revue de Medecine Interne. https://doi.org/10.1016/j.revmed.2009.03.364

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free