Markov chain methods in enzyme kinetics

Abstract

An enzyme cluster is a system of enzymes attached to a membrane, whose spatial organization makes it possible for the product of one enzymatic reaction tobe directly available as a substrate of another reaction within the cluster. We show how to model enzyme clusters by Markov chains, and how to compute their overall reaction rate. As a by-product we prove a formula for the number of completed cycles per unit time in a Markov chain. © 1982.