Maturation of ribosomal precursor RNA in Saccharomyces cerevisiae: A mutant with a defect in both the transport and terminal processing of the 20 S species

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Abstract

A mutant (CLP-8) of Saccharomyces cerevisiae possesses an abnormal ratio of native ribosomal subunits since it has an apparent deficiency of cytoplasmic 40 S subparticles. The mutant also has an abnormal anti-association factor activity. The lesion(s) responsible for the ribosomal subunit inbalance is not temperature-sensitive and is incomplete since the mutant still grows, albeit at a reduced rate compared to that of its parent. The lesion(s) in CLP-8 is, however, expressed at the level of 20 S ribosomal precursor RNA maturation. Thus, relative to the wild-type strain, there is both a slowed transport of 20 S ribosomal precursor RNA from the nucleus to the cytoplasm and a slowed cytoplasmic conversion of this RNA component into the mature 18 S form. © 1980, All rights reserved.

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Carter, C. J., & Cannon, M. (1980). Maturation of ribosomal precursor RNA in Saccharomyces cerevisiae: A mutant with a defect in both the transport and terminal processing of the 20 S species. Journal of Molecular Biology, 143(2), 179–199. https://doi.org/10.1016/0022-2836(80)90197-7

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