Mechanism of human placental aromatase: A new active site model

  • Oh S
  • Robinson C
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Abstract

Based on Akhtar's ferric peroxide mechanism and on recent studies in our own laboratory, we present a detailed proposal for aromatase action. This picture can account for the known stereochemical consequences at C-19 observed by others using isotopes of hydrogen and oxygen. The postulated process involves anchoring of the 19-hydroxymethyl and 19-oxo groups at the active site by a glutamate residue, which also serves to activate the 19-oxo group for attack by ferric peroxy species in the third oxidative step. © 1993.

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Authors

  • Soonsin S. Oh

  • Cecil H. Robinson

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