Medullary neurons with projections to lamina X of the rat as demonstrated by retrograde labeling after HRP microelectrophoresis

  • Du H
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Brainstem neurons were retrogradely labeled with microelectrophoresis of HRP or WGA-HRP into lamina X of the cervical or lumbar cord of rats. The results reveal that lamina X of the lumbar cord receives bulbar projections originating mainly within the nucleus rephe magnus and the nucleus reticularis paragigantocellularis (including the medial or α-ventral part and lateral part) and that lamina X of the cervical cord receives projections from similar but more extensive regions in the lower brainstem. These findings provide a neuroanatomical substrate for medullary descending modulation of nociceptive transmission in lamina X. © 1989.

Author-supplied keywords

  • Antinociception
  • Raphe-spinal projection
  • Retrograde tracing
  • Rexed's lamina X
  • Rostroventral medulla

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  • Huan Ji Du

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