Brainstem neurons were retrogradely labeled with microelectrophoresis of HRP or WGA-HRP into lamina X of the cervical or lumbar cord of rats. The results reveal that lamina X of the lumbar cord receives bulbar projections originating mainly within the nucleus rephe magnus and the nucleus reticularis paragigantocellularis (including the medial or α-ventral part and lateral part) and that lamina X of the cervical cord receives projections from similar but more extensive regions in the lower brainstem. These findings provide a neuroanatomical substrate for medullary descending modulation of nociceptive transmission in lamina X. © 1989.
Du, H. J. (1989). Medullary neurons with projections to lamina X of the rat as demonstrated by retrograde labeling after HRP microelectrophoresis. Brain Research, 505(1), 135–140. https://doi.org/10.1016/0006-8993(89)90124-8