Metal complexes of luteinizing hormone-releasing hormone (LHRH). Potentiometric and spectroscopic studies

  • Gerega K
  • Kozlowski H
  • Masiukiewicz E
 et al. 
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Abstract

The results are reported of a potentiometric and spectroscopic study of the H+, Cu2+, and Ni2+complexes of luteinizing hormone-releasing hormone (LHRH, HL) at 25°C and an ionic strength 0.10 mol dm-3(KNO3), since there is much evidence that the in vivo release of LHRH is influenced by the concentration of copper ions. With Cu2+the hormone has been shown to behave similarly to the thyrotropin releasing factor, forming a very stable [CuH-1L] complex involving coordination of three nitrogen donors: the Nimatom of the imidazole side chain and the two amido-N atoms of the pyroglutamylhistidyl unit. With Ni2+, coordination proceeds differently to give four nitrogen coordination. © 1988.

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Authors

  • Krystyna Gerega

  • Henryk Kozlowski

  • Elzbieta Masiukiewicz

  • Leslie D. Pettit

  • Simon Pyburn

  • Barbara Rzeszotarska

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