Metal complexes of luteinizing hormone-releasing hormone (LHRH). Potentiometric and spectroscopic studies

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Abstract

The results are reported of a potentiometric and spectroscopic study of the H+, Cu2+, and Ni2+complexes of luteinizing hormone-releasing hormone (LHRH, HL) at 25°C and an ionic strength 0.10 mol dm-3(KNO3), since there is much evidence that the in vivo release of LHRH is influenced by the concentration of copper ions. With Cu2+the hormone has been shown to behave similarly to the thyrotropin releasing factor, forming a very stable [CuH-1L] complex involving coordination of three nitrogen donors: the Nimatom of the imidazole side chain and the two amido-N atoms of the pyroglutamylhistidyl unit. With Ni2+, coordination proceeds differently to give four nitrogen coordination. © 1988.

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Gerega, K., Kozlowski, H., Masiukiewicz, E., Pettit, L. D., Pyburn, S., & Rzeszotarska, B. (1988). Metal complexes of luteinizing hormone-releasing hormone (LHRH). Potentiometric and spectroscopic studies. Journal of Inorganic Biochemistry, 33(1), 11–18. https://doi.org/10.1016/0162-0134(88)80030-8

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