Methodology for the testing of food dyes for genotoxic activity: Experiments with red 2G (C.I. 18050)

  • Haveland-Smith R
  • Combes R
  • Bridges B
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A methodology for investigating genotoxicity of food colours using the fluctuation and DNA-repair assays with bacteria is described. In addition, a liquid repair test, developed to permit incorporation of microsomes and the quantitative estimation of cell viability, has been characterised with a number of positive control agents. Results obtained in these systems suggest that the food colour Red 2G induces repairable DNA damage and base-substitution mutation, but only in the presence of a rat-liver microsomal preparation. The significance of the data in the light of other toxicological information is discussed. © 1979.

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  • R. B. Haveland-Smith

  • R. D. Combes

  • B. A. Bridges

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