A methodology for investigating genotoxicity of food colours using the fluctuation and DNA-repair assays with bacteria is described. In addition, a liquid repair test, developed to permit incorporation of microsomes and the quantitative estimation of cell viability, has been characterised with a number of positive control agents. Results obtained in these systems suggest that the food colour Red 2G induces repairable DNA damage and base-substitution mutation, but only in the presence of a rat-liver microsomal preparation. The significance of the data in the light of other toxicological information is discussed. © 1979.
Haveland-Smith, R. B., Combes, R. D., & Bridges, B. A. (1979). Methodology for the testing of food dyes for genotoxic activity: Experiments with red 2G (C.I. 18050). Mutation Research/Environmental Mutagenesis and Related Subjects, 64(4), 241–248. https://doi.org/10.1016/0165-1161(79)90093-1