The hemisynthesis of 1α-hydroxydrimenol has been selected to illustrate a synthetic route involving an initial microbial 3β-hydroxylation of a drimenol derivative followed by a functionalization transfer to position 1α, thus generating a new potentially bioactive hydroxylated terpenic compound. Several methods have been investigated for the protection and the regeneration of the 7,8-double bond of drimenyl derivatives. © 2001 Elsevier Science Ltd. All rights reserved.
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