The hemisynthesis of 1α-hydroxydrimenol has been selected to illustrate a synthetic route involving an initial microbial 3β-hydroxylation of a drimenol derivative followed by a functionalization transfer to position 1α, thus generating a new potentially bioactive hydroxylated terpenic compound. Several methods have been investigated for the protection and the regeneration of the 7,8-double bond of drimenyl derivatives. © 2001 Elsevier Science Ltd. All rights reserved.
Aranda, G., Cortés, M., Maurs, M., & Azerad, R. (2001). Microbiologically-assisted hemisynthesis of 1α-hydroxydrimenol. Tetrahedron Asymmetry, 12(14), 2013–2018. https://doi.org/10.1016/S0957-4166(01)00353-6