Microscale syntheses of anti-tumour platinum compounds labelled with191Pt

  • Baer J
  • Harrison R
  • McAuliffe C
 et al. 
  • 2

    Readers

    Mendeley users who have this article in their library.
  • 6

    Citations

    Citations of this article.

Abstract

Several compounds of platinum have been found to have significant anti-tumour activity and are in various stages of clinical trials. Four such compounds: cis-PtCl2(NH3)2, cis PtCl2(cyclopropylamine)2, cis,trans-PtCl2(OH)2(isopropylamine)2and cis-Pt(1,1-cyclobutanedicarboxylate)(NH3)2were synthesized with radioactive platinum-191 as a label for the study of animal organ distribution, patient blood clearance, urinary excretion and renal uptake and clearance. This paper describes the microscale synthesis of these compounds. Purification and quality control procedures are also described.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • J. Baer

  • R. Harrison

  • C. A. McAuliffe

  • A. Zaki

  • H. L. Sharma

  • A. G. Smith

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free