Mode of action of antitumour antibiotics-III: Modulation of permeability of nuclear membrane in the presence of the antibiotics

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Abstract

The binding characteristics of the antibiotics to nuclei and their effect on the permeability of nuclear membrane with respect to histones and ribonucleic acids have been investigated. The binding constant for chromomycin A3was found to be 1.4 × 104M-1and number of binding sites was equal to 3.48 ± 1.08 × 1012molecules/nuclei. The antibiotic chromomycin A3enhanced the uptake of lysine-rich histone, actinomycin D decreased the uptake and ethidium bromide had no effect. Chromomycin A3also enhanced the release of acid insoluble fraction containing RNA from the nuclei, actinomycin D and ethidium bromide inhibited the release of acid insoluble fraction containing RNA. The relevance of this finding to the role of nuclear envelope in understanding the mechanism of action of the antibiotic has been discussed. © 1978.

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Shashiprabha, B. K., & Podder, S. K. (1978). Mode of action of antitumour antibiotics-III: Modulation of permeability of nuclear membrane in the presence of the antibiotics. Biochemical and Biophysical Research Communications, 83(3), 933–940. https://doi.org/10.1016/0006-291X(78)91485-7

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