We have used a set of markers newly assigned to the proximal portion of mouse chromosome 1 to characterize the chromosomal segment deleted in the splotch-retarded (Spr) mouse mutant. Among nine markers tested in the heterozygote Spr/+ mouse, we have identified four genes, Vil, Des, Inha, and Akp-3, which map within the Sprdeletion. The closest distal marker to the deletion is the Acrg gene, with the distal deletion breakpoint mapping within the 0.8-cM segment separating Akp-3 and Acrg. The most proximal gene to the Sprdeletion is Tp1. The proximal deletion breakpoint maps within the 0.8-cM segment separating Tp1 and Vil. The minimum size of the Sprdeletion would therefore be limited to 14 cM, the genetic distance between Vil and Akp-3. The maximum size of the Sprdeletion is estimated to be 16 cM, the genetic distance between Tp1 and Acrg. © 1991.
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