Mutagenicity tests with styrene oxide in mammals

Citations of this article
Mendeley users who have this article in their library.
Get full text


The capability of styrene oxide to induce chromosome damage in vivo has been tested in the male mouse by examination of bone-marrow cells, by scoring micronuclei in polychromatic erythrocytes, by observation of meiotic chromosomes from treated males and by the dominant-lethality test. Furthermore, studies have been performed on short-term cultures of human lymphocytes in vitro. Whereas an increase in the yield of chromatid and chromosomal aberrations was observed after exposure in vitro, only negative results were obtained in the tests in vivo. One has, therefore, to conclude that styrene oxide isvpotentially capable of breaking mammalian chromosomes but that an exposure to an acute dose in vivo does not produce visible damage in somatic cells or in male germ cells. © 1978.




Fabry, L., Léonard, A., & Roberfroid, M. (1978). Mutagenicity tests with styrene oxide in mammals. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 51(3), 377–381.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free