N4-hydroxycytidine: A mutagen specific for at to GC transitions

  • Janion C
  • Glickman B
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Abstract

N4-Hydroxycytidine is a mutagen of the base-analog type and of the products formed by treatment of cytidine with hydroxylamine. In this communication evidence is presented showing that, in contrast with other known base analogs, N4-hydroxycytidine results mainly, if not exclusively, in AT → GC transitional alterations in Escherichia coli K12. © 1980, All rights reserved.

Author-supplied keywords

  • (oh)4CTP
  • (oh)4Cyd
  • 2-APur
  • 2-aminopurine
  • N4-hydroxycytidine
  • N4-hydroxycytidine-5′-triphosphate

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Authors

  • Celina Janion

  • Barry W. Glickman

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