Naltrexone prevents footshock-induced performance deficit in rats

  • McCubbin J
  • Kizer J
  • Lipton M
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Three experiments demonstrate that inescapable footshock delivered to unrestrained rats produces analgesia as well as performance deficits in subsequent one-way shuttle acquisition. Both the performance and the antinociceptive effects are prevented by pretreatment with as little as 0.1 mg/kg i.p. of the opiate antagonist, naltrexone. These studies suggest that both effects are mediated through opiate receptors with similar underlying naltrexone pharmacodynamics. © 1984.

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  • James A. McCubbin

  • John S. Kizer

  • Morris A. Lipton

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