Naltrexone prevents footshock-induced performance deficit in rats

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Abstract

Three experiments demonstrate that inescapable footshock delivered to unrestrained rats produces analgesia as well as performance deficits in subsequent one-way shuttle acquisition. Both the performance and the antinociceptive effects are prevented by pretreatment with as little as 0.1 mg/kg i.p. of the opiate antagonist, naltrexone. These studies suggest that both effects are mediated through opiate receptors with similar underlying naltrexone pharmacodynamics. © 1984.

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McCubbin, J. A., Kizer, J. S., & Lipton, M. A. (1984). Naltrexone prevents footshock-induced performance deficit in rats. Life Sciences, 34(21), 2057–2066. https://doi.org/10.1016/0024-3205(84)90370-9

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