N-carbamoyl analogs of Zafirlukast: Potent receptor antagonists of leukotriene D4

  • Brown M
  • Marfat A
  • Antognoli G
 et al. 
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Abstract

Exploration of the indole nitrogen region of Zafirlukast (1) has uncovered a potent series of cysteinyl leukotriene D4 (LTD4) antagonists. These studies showed that a variety of functionality could be incorporated in this region of the molecule without sacrificing potency. Efforts to exploit this site in order to improve oral efficacy are discussed.

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Authors

  • Matthew F. Brown

  • Anthony Marfat

  • Gerard Antognoli

  • Robert J. Chambers

  • John B. Cheng

  • David B. Damon

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