Nerve conduction velocity studies of workers employed in the manufacture of phenoxy herbicides

  • Singer R
  • Moses M
  • Valciukas J
 et al. 
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Conduction velocities (NCV) of the median motor, median sensory, and sural nerves were measured in 56 workers employed in the manufacture of 2,4,5-trichlorophenoxy acetic acid (2,4,5-T) and 2,4-dichlorophenoxy acetic acid (2,4-D). Mean age was 35 years and mean duration of employment was 7 years. The control group consisted of 25 subjects without exposure to neurotoxic agents. When compared with controls, slowing was noted in the sural nerve (mean = 34.0 vs 40.1 m/sec, P > 0.02). All values were then adjusted for age and temperature and were transformed to Z values (mean = 0, standard deviation = 1), where-upon slowing was seen in the sural (-2.21 vs -0.52, P < 0.0001) and median motor nerves (0.19 vs 0.91, P < 0.03). Duration of employment was significantly correlated with slowing of sural velocity (r = -0.40, P < 0.004). Altogether, 46% of the study group had one or more slowed nerve conduction velocity, versus 5% of the control group P < 0.001). © 1982.

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  • Raymond Singer

  • Marion Moses

  • José Valciukas

  • Ruth Lilis

  • Irving J. Selikoff

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