Procaine or tetrodotoxin microinjected into the midbrain increased temperatures of the interscapular brown adipose tissue (BAT) and rectum. L-Glutamate microinjected into the same area decreased these temperatures. Neurons in the inferior olive (IO) expressed c-fos following body temperature increase with midbrain procaine. Electrical stimulation of and glutamate injection into the IO increased body temperature, and IO lesions blocked the midbrain procaine-induced body temperature increase. Since decerebration of the hypothalamus had no effect on the temperature increase, it was concluded that neurons in the midbrain tonically inhibit BAT thermogenesis via IO neurons independently of the hypothalamus.
Mendeley saves you time finding and organizing research
Choose a citation style from the tabs below