Neuropeptide Y innervation of the rodent pineal gland and cerebral blood vessels

  • Schon F
  • Allen J
  • Yeats J
 et al. 
  • 2


    Mendeley users who have this article in their library.
  • 73


    Citations of this article.


Neuropeptide Y (NPY)-immunoreactivity has been shown to be present in sympathetic nerve fibres in the rat pineal gland and a dense network of NPY-containing nerve fibres demonstrated to innervate the rat circle of Willis. The NPY content of the major rabbit intracranial arteries was determined by radioimmunoassay and maximal levels found in the anterior cerebral arteries. After bilateral superior cervical ganglion (SCG) removal, no NPY was detectable in the rat pineal gland; however, significant NPY-immunoreactive nerve fibres remained throughout the rat vertebrobasilar arteries, and 47% of the assayable NPY was still present. Neither intraventricular 6-hydroxydopamine (6-OHDA) nor the combination of 6-OHDA treatment and SCG removal resulted in any further loss of NPY. In conclusion, the NPY innervation of the pineal gland originates exclusively from the peripheral sympathetic nervous system. In contrast the caudal portion of the rat circle of Willis contains NPY fibres which are resistant to sympathectomy. © 1985.

Author-supplied keywords

  • circle of Willis
  • neuropeptide Y
  • pineal gland
  • rat
  • superior cervical ganglionectomy

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • F. Schon

  • J. M. Allen

  • J. C. Yeats

  • Y. S. Allen

  • J. Ballesta

  • J. M. Polak

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free