A new bactericidal lead structure for the protection of materials

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Our search for a new broad spectrum bactericide for preserving materials lead to the discovery of a highly active bicyclic amine (1) and a number of derivatives. The synthesis and biological evaluation as well as a first toxicological assessment of these compounds are described. Compound 1 shows strong bactericidal activity down to levels of below 100 ppm but unfortunately increases the number of mutations in Ames tests. © 2004 Elsevier Ltd. All rights reserved.

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Vogl, E., Bruns, R., Kretschik, O., Uhr, H., Kaulen, J., Kugler, M., … Eberz, G. (2005). A new bactericidal lead structure for the protection of materials. Bioorganic and Medicinal Chemistry Letters, 15(3), 625–629. https://doi.org/10.1016/j.bmcl.2004.11.036

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