A new bactericidal lead structure for the protection of materials

  • Vogl E
  • Bruns R
  • Kretschik O
 et al. 
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Abstract

Our search for a new broad spectrum bactericide for preserving materials lead to the discovery of a highly active bicyclic amine (1) and a number of derivatives. The synthesis and biological evaluation as well as a first toxicological assessment of these compounds are described. Compound 1 shows strong bactericidal activity down to levels of below 100 ppm but unfortunately increases the number of mutations in Ames tests. © 2004 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Biocide
  • Lead structure

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Authors

  • Erasmus Vogl

  • Rainer Bruns

  • Oliver Kretschik

  • Hermann Uhr

  • Johannes Kaulen

  • Martin Kugler

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