New bis(1-ferrocenylethyl)amine-derived monodentate phosphoramidite ligands for highly enantioselective copper-catalyzed 1,4-conjugate addition

  • Zou D
  • Duan Z
  • Hu X
 et al. 
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A new family of chiral bis(1-ferrocenylethyl)amine-derived monodentate phosphoramidite ligands has been prepared and successfully applied in the Cu-catalyzed asymmetric 1,4-conjugate addition of diethylzinc to a variety of α,β-unsaturated compounds, in which up to 99% ee was obtained for nitroalkenes at -78 °C and >98% ee for cyclohexenone at -30 °C, comparable to or higher than those obtained with the most efficient monophosphoramidite ligands reported so far. © 2009 Elsevier Ltd. All rights reserved.

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  • Dong Yun Zou

  • Zheng Chao Duan

  • Xiang Ping Hu

  • Zhuo Zheng

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