A new deprotection strategy for automated oligonucleotide synthesis using a novel silyl-linked solid support

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Abstract

Automated solid phase synthesis of 2′-deoxyribose oligonucleotides; d(Tp)7T, d(Tps)7T and d(Tp)3(CBzp)2(Tp)2T, was achieved directly in 99% overall yields using a novel silyl linkage to a CPG silica support cleavable within seconds at room temperature using TBAF. © 1995.

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Routledge, A., Wallis, M. P., Ross, K. C., & Fraser, W. (1995). A new deprotection strategy for automated oligonucleotide synthesis using a novel silyl-linked solid support. Bioorganic and Medicinal Chemistry Letters, 5(18), 2059–2064. https://doi.org/10.1016/0960-894X(95)00368-4

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