A new deprotection strategy for automated oligonucleotide synthesis using a novel silyl-linked solid support

  • Routledge A
  • Wallis M
  • Ross K
 et al. 
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Abstract

Automated solid phase synthesis of 2′-deoxyribose oligonucleotides; d(Tp)7T, d(Tps)7T and d(Tp)3(CBzp)2(Tp)2T, was achieved directly in 99% overall yields using a novel silyl linkage to a CPG silica support cleavable within seconds at room temperature using TBAF. © 1995.

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Authors

  • Anne Routledge

  • Mark P. Wallis

  • Kenneth C. Ross

  • William Fraser

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