Nickel-catalyzed multi-component coupling reaction of aldimine, alkyne, and dimethylzinc via dimerization of butadiene

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Abstract

In the presence of a Ni/phosphine ligand catalyst, dimethylzinc, alkyne, butadiene, aldehyde, and primary amine were successively combined via dimerization of butadiene to provide (3E,7E,10Z)-dodecatrienylamine in good yields with excellent regio and stereoselectivities. © 2009 Elsevier Ltd. All rights reserved.

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Kimura, M., Togawa, M., Tatsuyama, Y., & Matsufuji, K. (2009). Nickel-catalyzed multi-component coupling reaction of aldimine, alkyne, and dimethylzinc via dimerization of butadiene. Tetrahedron Letters, 50(27), 3982–3984. https://doi.org/10.1016/j.tetlet.2009.04.086

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