N,N-disubstituted aminomethyl benzofuran derivatives: Synthesis and preliminary binding evaluation

  • Boyé S
  • Pfeiffer B
  • Renard P
 et al. 
  • 3

    Readers

    Mendeley users who have this article in their library.
  • 7

    Citations

    Citations of this article.

Abstract

A series of new N-substituted 2,3-dihydro-2-aminomethyl-2H-1-benzofuran derivatives was prepared and evaluated for affinity at 5-HT(1A), 5-HT(2A), 5-HT(2C), 5-HT3, D2, and D3receptors. Compound 9, 8-[4-[N-propyl-N-(7-hydroxy-2,3-dihydro-2H-1-benzofuran-2-yl)methyl]aminobutyl]-8-azaspiro[4,5]decane-7,9-dione, bound at 5-HT(1A) sites with nanomolar affinity (IC50=1.5nM) and high selectivity over 5-HT(2A), 5-HT(2C), 5-HT3, D2, and D3receptors. Copyright (C) 1999 Elsevier Science Ltd.

Author-supplied keywords

  • 2,3-Dihydro-2-aminomethyl-2H-1-benzofurans
  • Ring contraction
  • Serotoninergic and dopaminergic receptor binding

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Sophie Boyé

  • Bruno Pfeiffer

  • Pierre Renard

  • Marie Claire Rettori

  • Gérald Guillaumet

  • Marie Claude Viaud

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free